A 1.1 Mb duplication CNV on chromosome 17 contributes to skeletal muscle development in Boer goats.

ABSTRACT: The Boer goat is one of the top meat breeds in modern animal husbandry and has attracted widespread attention for its unique growth performance. However, the genetic basis of muscle development in the Boer goat remains obscure. In this study, we identified specific structural variants in the Boer goat based on genome-wide selection signals and analyzed the basis of the molecular heredity of related candidate genes in muscle development. A total of 9 959 autosomal copy number variations (CNVs) were identified through selection signal analysis in 127 goat genomes. Specifically, we confirmed that the highest signal CNV (HSV) was a chromosomal arrangement containing an approximately 1.11 Mb (CHIR17: 60062304-61171840 bp) duplicated fragment inserted in reverse orientation and a 5 362 bp delete

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC10083219 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature