The embryo mosaicism profile of next-generation sequencing PGT-A in different clinical conditions and their associations

ABSTRACT:

Introduction

Uniform chromosome abnormalities are commonly seen in early pregnancy loss, with analyses of the product of conception suggesting the presence of mosaic autosomal trisomy in ∼10% of cases. Although chromosomal mosaicism occurs in a minority of embryos, their relative commonality and uncertainty regarding associated transfer outcomes have created discussion at both the clinical and research levels, highlighting the need to understand the clinical conditions associated with the incidence of embryo mosaicism.

Methods

We took advantage of a preimplantation genetic testing for aneuploidy (PGT-A) database created from 2019 to 2022 in more than 160 in vitro fertilization (IVF) clinics in Brazil, the second-largest world market for IVF. We carried out descriptive sta

SUBMITTER: Heiser H 

PROVIDER: S-EPMC10083245 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature