Vaccinating women previously treated for human papillomavirus-related cervical precancerous lesions is highly cost-effective in China.

ABSTRACT:

Background

The 2021 Chinese Expert Consensus on the Clinical Application of the Human Papillomavirus (HPV) Vaccine recommended vaccination for women who previously received ablative or excisional treatment for high-grade squamous intraepithelial lesion (HSIL). This study evaluates the cost-effectiveness of HPV vaccination in women previously treated for cervical precancerous lesions.

Methods

We used a Markov model to simulate the disease progression of both low- and high-risk HPV subtypes. We followed a cohort of 100,000 women aged 18-45 years who received treatment for cervical precancerous lesions for a lifetime (80 years). We used the Incremental Cost-Effectiveness Ratios (ICER) with a 5% discount rate to measure the cost-effectiveness of nine vaccination strategies, incl

SUBMITTER: Zou M 

PROVIDER: S-EPMC10083292 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature