Decreased phase information transfer from the mPFC to the BLA: During exploratory behavior in CUMS rats.

ABSTRACT:

Introduction

Depression is a mental disorder characterized by aberrant exploratory behavior. Environmental factors, such as chronic stress, are commonly used to induce depression-like behavior in rodent models. The medial prefrontal cortex (mPFC) and the basolateral amygdala (BLA) are crucial sites in subjects with chronic stress-induced depression. The transmission of amplitude information from the mPFC to the BLA was abated during exploratory behavior in depressive rats; however, the nature of the phase interaction between these two sites remains unknown.

Methods

We used chronic unpredictable mild stress (CUMS) to model depression in rats and acquired local field potentials (LFPs) via multiple electrodes implanted in the mPFC and the BLA while rats (both the control and CU

SUBMITTER: Cao Q 

PROVIDER: S-EPMC10083315 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature