Discovering genetic linkage between periodontitis and type 1 diabetes: A bioinformatics study.

ABSTRACT: Background: Relationship between periodontitis (PD) and type 1 diabetes (T1D) has been reported, but the detailed pathogenesis requires further elucidation. This study aimed to reveal the genetic linkage between PD and T1D through bioinformatics analysis, thereby providing novel insights into scientific research and clinical treatment of the two diseases. Methods: PD-related datasets (GSE10334, GSE16134, GSE23586) and T1D-related datasets(GSE162689)were downloaded from NCBI Gene Expression Omnibus (GEO). Following batch correction and merging of PD-related datasets as one cohort, differential expression analysis was performed (adjusted p-value <0.05 and ∣log₂ fold change| > 0.5), and common differentially expressed genes (DEGs) between PD and T1D were extra

SUBMITTER: Liu J 

PROVIDER: S-EPMC10083320 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature