Development and validation of a unifying pre-treatment decision tool for intracranial and extracranial metastasis-directed radiotherapy

ABSTRACT:

Background

Though metastasis-directed therapy (MDT) has the potential to improve overall survival (OS), appropriate patient selection remains challenging. We aimed to develop a model predictive of OS to refine patient selection for clinical trials and MDT.

Patients and methods

We assembled a multi-institutional cohort of patients treated with MDT (stereotactic body radiation therapy, radiosurgery, and whole brain radiation therapy). Candidate variables for recursive partitioning analysis were selected per prior studies: ECOG performance status, time from primary diagnosis, number of additional non-target organ systems involved (NOS), and intracranial metastases.

Results

A database of 1,362 patients was assembled with 424 intracranial, 352 lung, and 607 spinal tre

SUBMITTER: Kowalchuk R 

PROVIDER: S-EPMC10083422 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature