The serum IgG antibody level as a biomarker for clinical outcome in patients with cerebral sparganosis after treatment.

ABSTRACT:

Introduction

Cerebral sparganosis is a rare parasitic infection of the brain tissue. The remission of MRI change and clinical symptom has been used to evaluate the therapeutic effect. However, there is no study to correlate the serum IgG antibody level of sparganum to the prognosis of disease after treatment.

Methods

87 patients with cerebral sparganosis were collected from three medical centers. Clinical symptoms and MRI changes were evaluated at 12 months after initial treatment, and serum IgG antibody level of sparganum was evaluated at 2, 6, and 12 months after treatment. The positive cut-off value was based on 2.1 times the optical density (OD) of negative control. The index value was defined as the sample OD divided by the cut-off value.

Results

Among the 87 pat

SUBMITTER: Xiang H 

PROVIDER: S-EPMC10083495 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature