Dataset Information

Clinical implications of gut microbiota and cytokine responses in coronavirus disease prognosis.

ABSTRACT:

Objectives

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects gut luminal cells through the angiotensin-converting enzyme-2 receptor and disrupts the gut microbiome. We investigated whether the gut microbiome in the early stage of SARS-CoV-2 infection was associated with the prognosis of coronavirus disease (COVID-19).

Methods

Thirty COVID-19 patients and 16 healthy controls were prospectively enrolled. Blood and stool samples and clinical details were collected on days 0 (enrollment), 7, 14, and 28. Participants were categorized into four groups by their clinical course.

Results

Gut microbiota composition varied during the clinical course of COVID-19 and was closely associated with cytokine levels (p=0.003). A high abundance of the genus Dialister (linear discriminant analysis [LDA] effect size: 3.97856, p=0.004), species Peptoniphilus lacrimalis (LDA effect size: 4.00551, p=0.020), and Anaerococcus prevotii (LDA effect size: 4.00885, p=0.007) was associated with a good prognosis. Starch, sucrose, and galactose metabolism was highly activated in the gut microbiota of the poor prognosis group. Glucose-lowering diets, including whole grains, were positively correlated with a good prognosis.

Conclusion

Gut microbiota may mediate the prognosis of COVID-19 by regulating cytokine responses and controlling glucose metabolism, which is implicated in the host immune response to SARS-CoV-2.

SUBMITTER: Seong H

PROVIDER: S-EPMC10083496 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Clinical implications of gut microbiota and cytokine responses in coronavirus disease prognosis.

Seong Hye H Kim Jun Hyoung JH Han Young-Hee YH Seo Ho Seong HS Hyun Hak Jun HJ Yoon Jin Gu JG Nham Eliel E Noh Ji Yun JY Cheong Hee Jin HJ Kim Woo Joo WJ Lim Sooyeon S Song Joon Young JY

Frontiers in immunology 20230324

<h4>Objectives</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects gut luminal cells through the angiotensin-converting enzyme-2 receptor and disrupts the gut microbiome. We investigated whether the gut microbiome in the early stage of SARS-CoV-2 infection was associated with the prognosis of coronavirus disease (COVID-19).<h4>Methods</h4>Thirty COVID-19 patients and 16 healthy controls were prospectively enrolled. Blood and stool samples and clinical details were collected ...[more]

PMID: 37051240

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Dataset Information

Clinical implications of gut microbiota and cytokine responses in coronavirus disease prognosis.

Objectives

Methods

Results

Conclusion

Publications

Clinical implications of gut microbiota and cytokine responses in coronavirus disease prognosis.

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