Dataset Information

Meningitis caused by extended-spectrum β-lactamase-producing Escherichia coli in infants in France: a case series.

ABSTRACT:

Objectives

We report the first case series focusing on clinical and biological characteristics of meningitis caused by ESBL-producing Escherichia coli in infants.

Methods

Between 2001 and 2020, data on all cases of E. coli meningitis were prospectively collected from a network of 259 paediatric wards and 168 microbiology laboratories in France. We analysed the clinical and biological characteristics, short-term complications and long-term sequelae of ESBL-producing E. coli meningitis cases in patients <6 months old.

Results

In total, 548 cases of E. coli paediatric meningitis were reported. ESBL-producing E. coli represented 12 (2.2%) cases. We included 10 patients aged <6 months old. Eight (80%) patients presented at least one sign of clinical severity: six needed mechanical ventilation, three presented signs of shock and one was in a coma. The overall short-term prognosis was good, with only one meningitis-attributed death in the first hours of care. All surviving children received carbapenems for a median of 21 days (range 9-28). Two relapses occurred, including one in a patient who received only 14 days of imipenem. We reported no long-term sequelae at a median follow-up of 20 months.

Conclusions

Meropenem seems to be the treatment of choice for ESBL-producing E. coli meningitis in children and needs to be given as early as possible (<48 h) and for at least 21 days. Maternal colonization or infection with ESBL-producing Enterobacteriaceae needs to be reported to the neonatal or paediatric ICU team, in order to adapt the empirical antibiotic therapy.

SUBMITTER: Lignieres G

PROVIDER: S-EPMC10083514 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Meningitis caused by extended-spectrum β-lactamase-producing <i>Escherichia coli</i> in infants in France: a case series.

Lignieres Gabriel G Rybak Alexis A Levy Corinne C Birgy André A Bechet Stéphane S Bonacorsi Stéphane S Cohen Robert R Madhi Fouad F

JAC-antimicrobial resistance 20230410 2

<h4>Objectives</h4>We report the first case series focusing on clinical and biological characteristics of meningitis caused by ESBL-producing <i>Escherichia coli</i> in infants.<h4>Methods</h4>Between 2001 and 2020, data on all cases of <i>E. coli</i> meningitis were prospectively collected from a network of 259 paediatric wards and 168 microbiology laboratories in France. We analysed the clinical and biological characteristics, short-term complications and long-term sequelae of ESBL-producing < ...[more]

PMID: 37051190

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