Novel Genetic Determinants of Dental Maturation in Children.

ABSTRACT: Dental occlusion requires harmonious development of teeth, jaws, and other elements of the craniofacial complex, which are regulated by environmental and genetic factors. We performed the first genome-wide association study (GWAS) on dental development (DD) using the Demirjian radiographic method. Radiographic assessments from participants of the Generation R Study (primary study population, N₁ = 2,793; mean age of 9.8 y) were correlated with ~30 million genetic variants while adjusting for age, sex, and genomic principal components (proxy for population stratification). Variants associated with DD at genome-wide significant level (P < 5 × 10^-8) mapped to 16q12.2 (IRX5) (lead variant rs3922616, B = 0.16; P = 2.2 × 10^-8). W

SUBMITTER: Grgic O 

PROVIDER: S-EPMC10083589 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature