Evolving landscape of clinical trials in gastroenteropancreatic neuroendocrine neoplasms in the past two decades.

ABSTRACT:

Background

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are heterogenous malignancies that require well-designed trials to develop effective management strategies. This cross-sectional study aimed to illustrate the current landscape of clinical trials in GEP-NENs to provide insights for future research.

Materials and methods

We reviewed all clinical trials registered on ClinicalTrials.gov between 1 January 2000 and 31 December 2021 with GEP-NEN in the 'condition or disease' field.

Results

We included 206 eligible trials. Most trials enrolled less than 50 patients (59.8%) and were sponsored by institutions other than government or industry (67.0%). Most trials were conducted in high-income countries (86.6%) and countries located in Europe (30.1%) or North

SUBMITTER: Yang K 

PROVIDER: S-EPMC10083666 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature