Faecal incontinence is associated with an impaired rectosigmoid brake and improved by sacral neuromodulation.

ABSTRACT:

Background

The rectosigmoid brake, characterised by retrograde cyclic motor patterns on high-resolution colonic manometry, has been postulated as a contributor to the maintenance of bowel continence. Sacral neuromodulation (SNM) is an effective therapy for faecal incontinence, but its mechanism of action is unclear. This study aims to investigate the colonic motility patterns in the distal colon of patients with faecal incontinence, and how these are modulated by SNM.

Methods

A high-resolution fibreoptic colonic manometry catheter, containing 36 sensors spaced at 1-cm intervals, was positioned in patients with faecal incontinence undergoing stage 1 SNM. One hour of pre- and post meal recordings were obtained followed by pre- and post meal recordings with suprasensory SNM. A

SUBMITTER: Lin AY 

PROVIDER: S-EPMC10084032 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature