Reproducibility of 3 T APT-CEST in Healthy Volunteers and Patients With Brain Glioma.

ABSTRACT:

Background

Amide proton transfer (APT) imaging is a chemical exchange saturation transfer (CEST) technique offering potential clinical applications such as diagnosis, characterization, and treatment planning and monitoring in glioma patients. While APT-CEST has demonstrated high potential, reproducibility remains underexplored.

Purpose

To investigate whether cerebral APT-CEST with clinically feasible scan time is reproducible in healthy tissue and glioma for clinical use at 3 T.

Study type

Prospective, longitudinal.

Subjects

Twenty-one healthy volunteers (11 females; mean age ± SD: 39 ± 11 years) and 6 glioma patients (3 females; 50 ± 17 years: 4 glioblastomas, 1 oligodendroglioma, 1 radiologically suspected low-grade glioma).

Field strength/sequence

3 T

SUBMITTER: Wamelink IJHG 

PROVIDER: S-EPMC10084114 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature