High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function.

ABSTRACT:

Introduction

The association between cognitive reserve (CR) and survival with independence is unknown. We examined whether lifelong CR accumulation is associated with disability-free survival and explored the extent to which cognitive function mediates this association.

Methods

Within the Rush Memory and Aging Project, 1633 dementia- and disability-free participants were followed annually for up to 22 years. Lifelong CR including education, early-/mid-/late-life cognitive activities, and late-life social activity was assessed and tertiled.

Results

CR score was dose-dependently associated with disability/death (hazard ratio [HR] 0.96, 95% confidence interval [CI] 0.93-0.99). Compared to low CR, the HR (95% CI) of disability/death was 0.82 (0.70-0.95) for high CR. The m

SUBMITTER: Li X 

PROVIDER: S-EPMC10084126 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature