Quantitative Magnetization EXchange MRI Measurement of Liver Fibrosis Model in Rodents.

ABSTRACT:

Background

Quantitative MRI can elucidate the complex microstructural changes in liver disease. The Magnetization EXchange (MEX) method estimates macromolecular fraction, such as collagen, and can potentially aid in this task.

Hypothesis

MEX sequence, and its derived quantitative macromolecular fraction, should correlate with collagen deposition in rodents liver fibrosis model.

Study type

Prospective.

Animal model

Sixteen adults Sprague-Dawley rats and 13 adults C57BL/6 strain mice given carbon tetrachloride (CCl₄ ) twice weekly for 6 or 8 weeks.

Field strength/sequence

A 7 T scanner. MEX sequence (selective suppression and magnetization exchange), spin-echo and gradient-echo scans.

Assessment

Macromolecular fraction (F) and T₁

SUBMITTER: Wilczynski E 

PROVIDER: S-EPMC10084184 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature