Histopathological liver steatosis linked with high parenteral glucose and amino acid supply in infants with short bowel syndrome.

ABSTRACT:

Background

Steatosis is a common feature of intestinal failure-associated liver disease (IFALD) in adult and older pediatric patients receiving long-term parenteral nutrition (PN). There are limited clinical data concerning steatosis in infants with short bowel syndrome (SBS). We investigated early histopathological steatosis and its association to PN.

Methods

In this retrospective study, 31 patients with SBS had a diagnostic liver biopsy taken at the median age of 5 (IQR 3-8) months. Follow-up biopsy was available for 24 patients at the median age of 29 (IQR 14-52) months. We evaluated the biopsies for steatosis and other histopathological signs of IFALD and compared results with patient characteristics, PN composition, and liver biochemistry.

Results

Diagnostic biop

SUBMITTER: Gunnar R 

PROVIDER: S-EPMC10084272 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature