Redefining the epidemiology of cardiac amyloidosis. A systematic review and meta-analysis of screening studies.

ABSTRACT:

Aims

An algorithm for non-invasive diagnosis of amyloid transthyretin cardiac amyloidosis (ATTR-CA) and novel disease-modifying therapies have prompted an active search for CA. We examined the prevalence of CA in different settings based on literature data.

Methods and results

We performed a systematic search for screening studies on CA, focusing on the prevalence, sex and age distribution in different clinical settings. The prevalence of CA in different settings was as follows: bone scintigraphy for non-cardiac reasons (n = 5 studies), 1% (95% confidence interval [CI] 0%-1%); heart failure with preserved ejection fraction (n = 6), 12% (95% CI 6%-20%); heart failure with reduced or mildly reduced ejection fraction (n = 2), 10% (95% CI 6%-15%); conduction disorders warranting

SUBMITTER: Aimo A 

PROVIDER: S-EPMC10084346 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature