Reduced exercise capacity is associated with left ventricular systolic dysfunction in long-term survivors of allogeneic hematopoietic stem-cell transplantation.

ABSTRACT:

Purpose

Exercise intolerance is a common complication in survivors of allogeneic hematopoietic stem-cell transplantation (allo-HSCT). The aim of this study was to determine if cardiac function measured with echocardiography is associated with exercise capacity measured with cardio-pulmonary exercise tests in long-term survivors treated in their youth with allo-HSCT.

Methods

The study included 96 patients, of which 54.2% were female, aged 34.9 ± 11.6 years and 17.7 ± 9.3 years after allo-HSCT. Reduced exercise capacity was defined as <85% of predicted-peak oxygen uptake (VO_2peak ). Linear regression was used in the prediction of VO_2peak (ml/kg/min). Receiver operating characteristic evaluated the accuracy of predicting reduced exercise capacity.

Resul

SUBMITTER: Massey RJ 

PROVIDER: S-EPMC10084426 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature