Portal pressure is of significant prognostic value in primary biliary cholangitis.

ABSTRACT:

Background and aims

In other forms of chronic liver disease, measurement of portal pressure is of prognostic value, but this has not yet been established in primary biliary cholangitis (PBC). The aim of the study is to determine the prognostic value of hepatic venous pressure gradient (HVPG) in relation to liver-related survival outcomes, as well as to the development of hepatic decompensation, oesophageal varices and variceal bleeding.

Methods

Baseline HVPG and liver biopsies were obtained in 86 patients followed for 10 years in a controlled trial of colchicine treatment, and subsequently in a long-term observational cohort study for a further 30 years.

Results

There were 49 Hepatic deaths in addition to 10 Liver Transplants (Hepatic death/transplant; n = 59). Some o

SUBMITTER: Warnes TW 

PROVIDER: S-EPMC10084443 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature