Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups.

ABSTRACT:

Introduction

While complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through different pattern recognition molecules, including mannan binding lectin (MBL), a protein shown to interact with SARS-CoV-2 proteins. However, the exact role of lectin pathway activation and its key pattern recognition molecule MBL in COVID-19 is still not fully understood.

Methods

We therefore investigated activation of the lectin pathway in two independent cohorts of SARS-CoV-2 infected patients, while also analysing MBL protein levels and potential effects of the six major single nucleotide polymorphisms (SNPs) found in the MBL2

SUBMITTER: Hurler L 

PROVIDER: S-EPMC10084477 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature