No effects on heart rate variability in depression after treatment with dorsomedial prefrontal intermittent theta burst stimulation.

ABSTRACT:

Background

The purpose of this study was to investigate whether treatment of a depressive episode with intermittent theta burst stimulation (iTBS) over the dorsomedial prefrontal cortex (DMPFC) had any effects on heart rate variability (HRV). We also investigated if changes in HRV covaried with symptom change after iTBS and if HRV could predict symptom change.

Methods

We included 49 patients with a current depressive episode. All were randomized to receive a double-blind treatment course with active or sham iTBS over the DMPFC. HRV data were obtained from 1 h of night data before and after the iTBS. The standard deviation of the RR interval (SDNN) was chosen as primary outcome measure. Depressive, negative, and anxiety symptoms as well as self-rated health were assessed by c

SUBMITTER: Bengtsson J 

PROVIDER: S-EPMC10084494 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature