Metformin adherence and the risk of cardiovascular disease: a population-based cohort study.

ABSTRACT:

Background

Metformin is a potent antiglycemic agent, but its importance has receded owing to the launch of novel antidiabetic medications. The benefit of metformin includes not only blood sugar control but also anti-inflammation, autophagy activation, and neuroprotection. This study investigated the risk of cardiovascular disease (CVD) in people with type II diabetes mellitus (T2DM) who adhered to metformin after adding on a second-line antiglycemic agent.

Objectives

The purpose of this study was to investigate the benefits of metformin in CVD prevention in patients with T2DM.

Design

We designed the study by comparing the incident rate of CVD events in patients with T2DM who received metformin continually and who ceased metformin during 2002-2014.

Methods

Medic

SUBMITTER: Yu SF 

PROVIDER: S-EPMC10084537 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature