High TXNIP expression accelerates the migration and invasion of the GDM placenta trophoblast.

ABSTRACT:

Introduction

Our previous study has proofed the glucose sensitive gene-thioredoxin-interacting protein (TXNIP) expression was up in the placenta of the patients with gestational diabetes mellitus (GDM), but the pathological mechanisms underlying abnormal TXNIP expression in the placenta of patients with GDM is completely unclear and additional investigations are required to explain the findings we have observed. In the present study, we simulated the high TXNIP expression via introducing the Tet-On "switch" in vitro, approximate to its expression level in the real world, to explore the following consequence of the abnormal TXNIP.

Methods

The expression and localization of TXNIP in the placenta of GDM patients and the health control was investigated via immunofluorescent stai

SUBMITTER: Sa R 

PROVIDER: S-EPMC10084645 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature