Biomimetic liposomal nanozymes improve breast cancer chemotherapy with enhanced penetration and alleviated hypoxia.

ABSTRACT:

Background

Doxorubicin (Dox) has been recommended in clinical guidelines for the standard-of-care treatment of breast cancer. However, Dox therapy faces challenges such as hypoxia, acidosis, H₂O₂-rich conditions and condensed extracellular matrix in TME as well as low targeted ability.

Methods

We developed a nanosystem H-MnO₂-Dox-Col NPs based on mesoporous manganese dioxide (H-MnO₂) in which Dox was loaded in the core and collagenase (Col) was wrapped in the surface. Further the H-MnO₂-Dox-Col NPs were covered by a fusion membrane (MP) of inflammation-targeted RAW264.7 cell membrane and pH-sensitive liposomes to form biomimetic MP@H-MnO₂-Dox-Col for in vitro and in vivo study.

Results

Our results shows

SUBMITTER: Li J 

PROVIDER: S-EPMC10084658 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature