Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway.

ABSTRACT:

Background

Liver fibrosis and hepatocellular carcinogenesis secondary to liver fibrosis are serious liver diseases with no effective treatments. Mori fructus aqueous extracts (MFAEs) have served as successful treatments for many types of liver injury including fibrosis although the molecular mechanisms are unknown at present.

Purpose

To investigate the effect of MFAEs in alleviating acute and chronic liver injury and tried to decipher the underlying mechanism.

Methods and results

Mice were divided into 5 groups (n = 8) for acute (groups: control, 0.3% CCl₄, bifendate (BD), 100 and 200 mg/kg MFAEs, 7 d) and chronic (groups: control, 10% CCl₄, BD, 100 and 200 mg/kg MFAEs, 4 weeks) liver injury study. Each mouse was injected intraperitoneally with 1

SUBMITTER: Wei Y 

PROVIDER: S-EPMC10084661 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature