Photobiomodulation therapy mitigates cardiovascular aging and improves survival.

ABSTRACT:

Background

Photobiomodulation (PBM) therapy, a form of low-dose light therapy, has been noted to be effective in several age-associated chronic diseases such as hypertension and atherosclerosis. Here, we examined the effects of PBM therapy on age-associated cardiovascular changes in a mouse model of accelerated cardiac aging.

Methods

Fourteen months old Adenylyl cyclase type VIII (AC8) overexpressing transgenic mice (n = 8) and their wild-type (WT) littermates (n = 8) were treated with daily exposure to Near-Infrared Light (850 nm) at 25 mW/cm² for 2 min each weekday for a total dose of 1 Einstein (4.5 p.J/cm² or fluence 3 J/cm² ) and compared to untreated controls over an 8-month period. PBM therapy was administered for 3.5 months (Early Tre

SUBMITTER: Syed SB 

PROVIDER: S-EPMC10084725 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature