Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury.

ABSTRACT: Experience-dependent white matter plasticity offers new potential for rehabilitation-induced recovery after neurotrauma. This first-in-human translational experiment combined myelin water imaging in humans and genetic fate-mapping of oligodendrocyte lineage cells in mice to investigate whether downhill locomotor rehabilitation that emphasizes eccentric muscle actions promotes white matter plasticity and recovery in chronic, incomplete spinal cord injury (SCI). In humans, of 20 individuals with SCI that enrolled, four passed the imaging screen and had myelin water imaging before and after a 12-week (3 times/week) downhill locomotor treadmill training program (SCI + DH). One individual was excluded for imaging artifacts. Uninjured control participants (n = 7) had two myelin water imaging ses

SUBMITTER: Faw TD 

PROVIDER: S-EPMC10084731 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature