Low dose vs high dose tocilizumab in COVID-19 patients with hypoxemic respiratory failure.

ABSTRACT:

Purpose

Tocilizumab has been shown to decrease mortality when used concomitantly with steroids in COVID-19 with 8 mg/kg (max 800 mg) being the standard dose. Our study sought to assess whether a low dose (400 mg) shows similar benefit compared to a high dose for COVID patients concurrently on the same median dose of steroids.

Materials/methods

A retrospective, multihospital observational study of COVID-19 patients who received tocilizumab in conjunction with steroids between March 2020 and August 2021 was conducted.

Results

A total of 407 patients were analyzed with low dose group being significantly more ill at baseline as a higher percentage of patients received vasopressors, were admitted to the ICU and on mechanical ventilation. In the propensity-matched analysis,

SUBMITTER: Chung J 

PROVIDER: S-EPMC10084735 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature