Deletion of IL-17ra in osteoclast precursors increases bone mass by decreasing osteoclast precursor abundance.

ABSTRACT: Metabolic bone diseases, such as osteoporosis, typically reflect an increase in the number and activity of bone-resorbing osteoclasts that result in a loss of bone mass. Inflammatory mediators have been identified as drivers of both osteoclast formation and activity. The IL-17 family of inflammatory cytokines has gained attention as important contributors to both bone formation and resorption. The majority of IL-17 cytokines signal through receptor complexes containing IL-17a receptor (IL-17ra); however, the role of IL-17ra signaling in osteoclasts remains elusive. In this study, we conditionally deleted Il17ra in osteoclast precursors using LysM-Cre and evaluated the phenotypes of skeletally mature male and female conditional knockout and control mice. The conditional knockout mice displa

SUBMITTER: Roberts JL 

PROVIDER: S-EPMC10084774 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature