Alteration of the gut microbiome and correlated metabolism in a rat model of long-term depression.

ABSTRACT:

Objective

This study aims to investigate the composition and function of the gut microbiome in long-term depression using an 8-week chronic unpredictable mild stress (CUMS) rat model.

Materials and methods

Animals were sacrificed after either 4 weeks or 8 weeks under CUMS to mimic long-term depression in humans. The gut microbiome was analyzed to identify potential depression-related gut microbes, and the fecal metabolome was analyzed to detect their functional metabolites. The correlations between altered gut microbes and metabolites in the long-term depression rats were explored. The crucial metabolic pathways related to long-term depression were uncovered through enrichment analysis based on these gut microbes and metabolites.

Results

The microbial composition of l

SUBMITTER: Li Y 

PROVIDER: S-EPMC10084793 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature