Association between statin use and risk of gallstone disease and cholecystectomy: a meta-analysis of 590,086 patients.

ABSTRACT:

Background

Statins have been reported to reduce the risk of gallstone disease. However, the impacts of different durations of statin use on gallstone disease have not been clarified. The aim of this study is toperform a systematic review with meta-analysis to update and to elucidate the association between statin use and the risk of gallstone disease and cholecystectomy.

Methods

Medline, Embase and Cochrane Library were searched from the inception until August 2022 for relevant articles investigating the difference in the risk of gallstone disease between statin users and non-users (PROSPERO, ID: CRD42020182445). Meta-analyses were conducted using odds ratios (ORs) with corresponding 95% confidence intervals (CIs) to compare the risk of gallstone disease and cholecystectomy

SUBMITTER: Chang Y 

PROVIDER: S-EPMC10084820 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature