Reduction of host cell mitochondrial activity as Mycobacterium leprae's strategy to evade host innate immunity.

ABSTRACT: Leprosy is a much-feared incapacitating infectious disease caused by Mycobacterium leprae or M lepromatosis, annually affecting roughly 200,000 people worldwide. During host-pathogen interaction, M leprae subverts the immune response, leading to development of disease. Throughout the last few decades, the impact of energy metabolism on the control of intracellular pathogens and leukocytic differentiation has become more evident. Mitochondria play a key role in regulating newly-discovered immune signaling pathways by controlling redox metabolism and the flow of energy besides activating inflammasome, xenophagy, and apoptosis. Likewise, this organelle, whose origin is probably an alphaproteobacterium, directly controls the intracellular pathogens attempting to invade its niche, a feature con

SUBMITTER: Oliveira MF 

PROVIDER: S-EPMC10084840 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature