Phenotyping Superagers Using Resting-State fMRI.

ABSTRACT:

Background and purpose

Superagers are defined as older adults with episodic memory performance similar or superior to that in middle-aged adults. This study aimed to investigate the key differences in discriminative networks and their main nodes between superagers and cognitively average elderly controls. In addition, we sought to explore differences in sensitivity in detecting these functional activities across the networks at 3T and 7T MR imaging fields.

Materials and methods

Fifty-five subjects 80 years of age or older were screened using a detailed neuropsychological protocol, and 31 participants, comprising 14 superagers and 17 cognitively average elderly controls, were included for analysis. Participants underwent resting-state-fMRI at 3T and 7T MR imaging. A predictio

SUBMITTER: de Godoy LL 

PROVIDER: S-EPMC10084893 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature