Meta-analysis and trial sequential analysis of ezetimibe for coronary atherosclerotic plaque compositions.

ABSTRACT: Background: Lipid aggregation, inflammatory cell infiltration, fibrous cap formation, and disruption are the major causes of atherosclerotic cardiovascular disease (ASCVD) and the pathologic features of atherosclerotic plaques. Although ezetimibe's role in decreasing blood lipids is widely known, there are insufficient data to determine which part of the drug has an effect on atherosclerotic plaque compositions. Objective: The study aimed to systematically evaluate the efficacy of ezetimibe for coronary atherosclerotic plaque compositions. Methods: Two researchers independently searched the PubMed, Embase, Cochrane Library, and Web of Science databases for randomized controlled trials (RCTs) on the efficacy of ezetimibe for coronary atherosclerotic plaques from incepti

SUBMITTER: Chai B 

PROVIDER: S-EPMC10084938 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature