Targeted activation of Nrf2/HO-1 pathway by Corynoline alleviates osteoporosis development.

ABSTRACT: Oxidative stress is preferentially treated as a risk factor for the development and progression of osteoporosis. Corynoline as a component of Corydalis bungeana Turcz presents antioxidative and anti-inflammatory properties. In the present study, the effects of Corynoline on osteoblasts following hydrogen peroxide (H₂O₂)-induced injury were evaluated accompanied by the investigation of the molecular mechanisms involved. It was found that Corynoline downregulated the intracellular reactive oxygen species (ROS) generation and restored the osteogenic potential of the disrupted osteoblasts by H₂O₂ exposure. Furthermore, Corynoline was revealed to activate the Nrf2/HO-1 signaling pathway, while ML385 (an Nrf2 inhibitor) would prevent the Corynoline-med

SUBMITTER: Xu TH 

PROVIDER: S-EPMC10084958 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature