A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850.

ABSTRACT:

Background

Overexpression of metabotropic glutamate receptor 1 (GRM1) has been implicated in the pathogenesis of multiple cancers. Riluzole, an inhibitor of glutamate release, showed synergistic antitumor activity in combination with the multi-kinase inhibitor sorafenib in preclinical models. This phase I trial identified the toxicity profile, dose-limiting toxicities, maximum tolerated dose (MTD), and pharmacokinetic and pharmacodynamic properties of riluzole combined with sorafenib in patients with advanced cancers.

Patients and methods

Patients with refractory solid tumors were enrolled utilizing a 3+3 dose-escalation design. Riluzole was given at 100 mg PO BID in combination with sorafenib, beginning at 200 mg PO daily and escalating in 200 mg increments per level in 28-

SUBMITTER: Spencer KR 

PROVIDER: S-EPMC10085060 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature