Reduction of NgR in perforant path protects neuronal morphology and function in APP/PS1 transgenic mice.

ABSTRACT: Neuronal loss is the central abnormality occurring in brains suffering from Alzheimer's disease (AD). The notion that AD causes the death of neurons point towards protection of neuronal morphology and function as important therapeutic strategies. The perforant path projections from the entorhinal cortex to the dentate gyrus is the most vulnerable circuit with respect to AD. It's known that the perforant path is a very important structure for synaptic plasticity and cognitive functions. NgR (Nogo receptor) is not only involved in limiting injury-induced axonal growth but also in pathological features of AD. So, the mechanism of how NgR affects the perforant path needs further investigation. In this study, the effect of NgR in the perforant path on the neuronal morphology and function in APP

SUBMITTER: Jiang R 

PROVIDER: S-EPMC10085588 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature