Development a m⁶A regulators characterized by the immune cell infiltration in stomach adenocarcinoma for predicting the prognosis and immunotherapy response.

ABSTRACT: N6-Methyladenosine (m⁶A) has attracted growing interest among scholars as an important regulator of mRNA expression. Although the significant role of m⁶A in multiple biological processes (like proliferation and growth of cancers) has been comprehensively described, an analysis of its possible role in stomach adenocarcinoma (STAD) of tumor immune microenvironment (TIME) remains lacking. The data for RNA expression, single nucleotide polymorphism (SNP), and copy number variation (CNV) were downloaded from The Cancer Genome Atlas (TCGA). Subsequently, 23 m⁶A regulators were curated, with patients being clustered into three m⁶A subtypes and m⁶A-related gene subtypes. Furthermore, they were compared based on overall survival (OS). This stud

SUBMITTER: Shi G 

PROVIDER: S-EPMC10085598 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature