RNA virus-mediated changes in organismal oxygen consumption rate in young and old Drosophila melanogaster males.

ABSTRACT: Aging is accompanied by increased susceptibility to infections including with viral pathogens resulting in higher morbidity and mortality among the elderly. Significant changes in host metabolism can take place following virus infection. Efficient immune responses are energetically costly, and viruses divert host molecular resources to promote their own replication. Virus-induced metabolic reprogramming could impact infection outcomes, however, how this is affected by aging and impacts organismal survival remains poorly understood. RNA virus infection of Drosophila melanogaster with Flock House virus (FHV) is an effective model to study antiviral responses with age, where older flies die faster than younger flies due to impaired disease tolerance. Using this aged host-virus model, w

SUBMITTER: Hagedorn E 

PROVIDER: S-EPMC10085608 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature