P53/miR-34a/SIRT1 positive feedback loop regulates the termination of liver regeneration.

ABSTRACT:

Background

The capacity of the liver to restore its architecture and function assures good prognoses of patients who suffer serious hepatic injury, cancer resection, or living donor liver transplantation. Only a few studies have shed light on the mechanisms involved in the termination stage of LR. Here, we attempt to further verify the role of the p53/miR-34a/SIRT1 positive feedback loop in the termination of liver regeneration and its possible relationship with liver cancer.

Method

We performed partial hepatectomy (PH) in mice transfected with adenovirus (Ade) overexpressing P53 and adenovirus-associated virus (AAV) overexpressing miR-34a. LR was analyzed by liver weight/body weight, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and cell p

SUBMITTER: Gong J 

PROVIDER: S-EPMC10085612 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature