Novel and replicated clinical and genetic risk factors for toxicity from high-dose methotrexate in pediatric acute lymphoblastic leukemia.

ABSTRACT:

Study objective

Methotrexate (MTX) is a key component of treatment for high-risk pediatric acute lymphoblastic leukemia (ALL) but may cause acute kidney injury and prolonged hospitalization due to delayed clearance. The purpose of this study is to identify clinical and genetic factors that may predict which children are at risk for creatinine increase and prolonged MTX clearance.

Design

We conducted a single-center, retrospective cohort study of pediatric patients with ALL who received 4000-5000 mg/m² of MTX. Measurements We performed germline genotyping to determine genetic ancestry and allele status for 49 single nucleotide polymorphisms (SNPs) identified from the literature as related to MTX disposition. Bayesian hierarchical ordinal regression models for creat

SUBMITTER: Zobeck M 

PROVIDER: S-EPMC10085626 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature