Novel potential drugs for the treatment of primary open-angle glaucoma using protein-protein interaction network analysis.

ABSTRACT: Glaucoma is the second leading cause of irreversible blindness, and primary open-angle glaucoma (POAG) is the most common type. Due to inadequate diagnosis, treatment is often not administered until symptoms occur. Hence, approaches enabling earlier prediction or diagnosis of POAG are necessary. We aimed to identify novel drugs for glaucoma through bioinformatics and network analysis. Data from 36 samples, obtained from the trabecular meshwork of healthy individuals and patients with POAG, were acquired from a dataset. Next, differentially expressed genes (DEGs) were identified to construct a protein-protein interaction (PPI) network. In both stages, the genes were enriched by studying the critical biological processes and pathways related to POAG. Finally, a drug-gene network was construc

SUBMITTER: Zavarzadeh PG 

PROVIDER: S-EPMC10085733 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature