Antibiotic resistance in Neisseria gonorrhoeae: broad-spectrum drug target identification using subtractive genomics.

ABSTRACT: Neisseria gonorrhoeae is a Gram-negative aerobic diplococcus bacterium that primarily causes sexually transmitted infections through direct human sexual contact. It is a major public health threat due to its impact on reproductive health, the widespread presence of antimicrobial resistance, and the lack of a vaccine. In this study, we used a bioinformatics approach and performed subtractive genomic methods to identify potential drug targets against the core proteome of N. gonorrhoeae (12 strains). In total, 12,300 protein sequences were retrieved, and paralogous proteins were removed using CD-HIT. The remaining sequences were analyzed for non-homology against the human proteome and gut microbiota, and screened for broad-spectrum analysis, druggability, and anti-target analysis. The protein

SUBMITTER: Omeershffudin UNM 

PROVIDER: S-EPMC10085745 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature