Nanosonosensitizers-engineered injectable thermogel for augmented chemo-sonodynamic therapy of melanoma and infected wound healing.

ABSTRACT: Easy recurrence and bacteria infected-wound healing after surgery excision pose severe challenges to clinical melanoma therapy. Herein, an injectable CuO₂ nanodots-engineered thermosensitive chitosan hydrogel (CuO₂-BSO@Gel) for enhanced melanoma chemo-sonodynamic therapy and improved infected wound healing was rationally constructed by facilely integrating the CuO₂ nanodots and L-Buthionine-(S, R)-sulfoximine (BSO) with thermoresponsive hydrogel. Favored by the Fenton catalytic activity of Cu²⁺, the CuO₂ nanodots can achieve enhanced chemodynamic therapy (CDT) by self-supplying H₂O₂ under acidic tumor microenvironment. Simultaneously, the CuO₂ nanodots with a narrow bandgap (2.29 ​eV) were proven to be

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC10085782 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature