Primary care physician use of patient race and polygenic risk scores in medical decision-making.

ABSTRACT:

Purpose

The use of patient race in medicine is controversial for its potential either to exacerbate or address health disparities. Polygenic risk scores (PRSs) have emerged as a tool for risk stratification models used in preventive medicine. We examined whether PRS results affect primary care physician (PCP) medical decision-making and whether that effect varies by patient race.

Methods

Using an online survey with a randomized experimental design among PCPs in a national database, we ascertained decision-making around atherosclerotic cardiovascular disease prevention and prostate cancer screening for case scenario patients who were clinically identical except for randomized reported race.

Results

Across 369 PCPs (email open rate = 10.8%, partial completion rate = 93.

SUBMITTER: Kerman BJ 

PROVIDER: S-EPMC10085844 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature