Optical coherence tomography reveals retinal thinning in schizophrenia spectrum disorders.

ABSTRACT:

Background

Schizophrenia spectrum disorders (SSDs) are presumed to be associated with retinal thinning. However, evidence is lacking as to whether these retinal alterations reflect a disease-specific process or are rather a consequence of comorbid diseases or concomitant microvascular impairment.

Methods

The study included 126 eyes of 65 patients with SSDs and 143 eyes of 72 healthy controls. We examined macula and optic disc measures by optical coherence tomography (OCT) and OCT angiography (OCT-A). Additive mixed models were used to assess the impact of SSDs on retinal thickness and perfusion and to explore the association of retinal and clinical disease-related parameters by controlling for several ocular and systemic covariates (age, sex, spherical equivalent, intraocula

SUBMITTER: Boudriot E 

PROVIDER: S-EPMC10085905 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature