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Association between smoking and all-cause mortality in Parkinson's disease.


ABSTRACT: We aimed to investigate the association between smoking status and all-cause mortality of Parkinson's disease (PD). Among the whole nationwide population data from Korea National Health Insurance Service, newly diagnosed PD was selected, and all-cause mortality was evaluated. The systematic review was performed through a literature search on the PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases. Among 26,080 individuals with PD, there was no significant association between smoking status and all-cause mortality in a nationwide cohort study (ex-smoker, HR 0.1.03, 95% CI 0.97-1.10; current smoker, HR 1.06, 95% CI 0.96-1.16). The systematic review, including six prospective cohort studies, also found a nonsignificant association. PD smokers tended to have fewer deaths from neurologic causes but were significantly more likely to die from smoking-related cancers such as lung cancer. We presented a nonsignificant association between smoking and mortality of PD, and cigarette smoking is not recommended in individuals with PD.

SUBMITTER: Yoon SY 

PROVIDER: S-EPMC10085986 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Association between smoking and all-cause mortality in Parkinson's disease.

Yoon Seo Yeon SY   Park You Hyun YH   Lee Sang Chul SC   Suh Jee Hyun JH   Yang Seung Nam SN   Kang Dae Ryong DR   Kim Yong Wook YW  

NPJ Parkinson's disease 20230411 1


We aimed to investigate the association between smoking status and all-cause mortality of Parkinson's disease (PD). Among the whole nationwide population data from Korea National Health Insurance Service, newly diagnosed PD was selected, and all-cause mortality was evaluated. The systematic review was performed through a literature search on the PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases. Among 26,080 individuals with PD, there was no significant association bet  ...[more]

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