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LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway.

ABSTRACT: Long-form collapsin response mediator protein-1 (LCRMP-1) belongs to the CRMP family which comprises brain-enriched proteins responsible for axon guidance. However, its role in spermatogenesis remains unclear. Here we find that LCRMP-1 is abundantly expressed in the testis. To characterize its physiological function, we generate LCRMP-1-deficient mice (Lcrmp-1-/-). These mice exhibit aberrant spermiation with apoptotic spermatids, oligospermia, and accumulation of immature testicular cells, contributing to reduced fertility. In the seminiferous epithelial cycle, LCRMP-1 expression pattern varies in a stage-dependent manner. LCRMP-1 is highly expressed in spermatids during spermatogenesis and especially localized to the spermiation machinery during spermiation. Mechanistically, LCRMP-1 deficiency causes disorganized F-actin due to unbalanced signaling of F-actin dynamics through upregulated PI3K-Akt-mTOR signaling. In conclusion, LCRMP-1 maintains spermatogenesis homeostasis by modulating cytoskeleton remodeling for spermatozoa release.

SUBMITTER: Chang JH 

PROVIDER: S-EPMC10086033 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway.

Chang Jung-Hsuan JH   Chou Chia-Hua CH   Wu Jui-Ching JC   Liao Keng-Mao KM   Luo Wei-Jia WJ   Hsu Wei-Lun WL   Chen Xuan-Ren XR   Yu Sung-Liang SL   Pan Szu-Hua SH   Yang Pan-Chyr PC   Su Kang-Yi KY  

Communications biology 20230410 1

Long-form collapsin response mediator protein-1 (LCRMP-1) belongs to the CRMP family which comprises brain-enriched proteins responsible for axon guidance. However, its role in spermatogenesis remains unclear. Here we find that LCRMP-1 is abundantly expressed in the testis. To characterize its physiological function, we generate LCRMP-1-deficient mice (Lcrmp-1<sup>-/-</sup>). These mice exhibit aberrant spermiation with apoptotic spermatids, oligospermia, and accumulation of immature testicular  ...[more]

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