Application of a novel deep eutectic solvent as a capable and new catalyst for the synthesis of tetrahydropyridines and 1,3-thiazolidin-4-ones.

ABSTRACT: A novel deep eutectic solvent (ETPP-Br/THF-TCA-DES) was prepared by a mixture of ethyl triphenylphosphonium bromide (ETPP-Br) and tetrahydrofuran-2,3,4,5-tetra-carboxylic acid (THF-TCA, mole ratio 7:3), characterized by FT-IR, TGA/DTA, densitometer, eutectic point, and ¹H NMR techniques and used as a capable and new catalyst for the synthesis of two sets of compounds: (1) the four new [a(1-4)] and the eleven [a(5-15)] known alkyl 1,2,6-trisubstituted-4-[(hetero)arylamino]-1,2,5,6-tetrahydropyridine-3-carboxylates and (2) the two new [b(1-2)] and the eight [b(3-10)] known 1,3-thiazolidin-4-ones in DES with short reaction time, high yields, and easy recycling and separation of the DES catalyst. There is a nice consistency between the proposed structure of the DES compound, the int

SUBMITTER: Goudarzi H 

PROVIDER: S-EPMC10086034 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature