The prognostic and immunological role of MYB: from bladder cancer validation to pan-cancer analysis.

ABSTRACT:

Background

MYB proto-oncogene is verified as a transcription factor. Although emerging evidence showed that MYB plays a critical part in tumor progression and immunity, a systematic pan-cancer analysis of MYB still remains to be performed for determining whether MYB could serve as a biomarker for cancer screening, prognosis prediction and accurate therapy design in various human cancers.

Methods

In the present study, we performed qRT-PCR, wound healing assay and transwell assay to validate the expression level and biological function of MYB in bladder cancer. Then, we utilized several open-source databases including UCSC Xena database, TCGA, GTEx, etc. Online tools was used to process the raw data from UCSC Xena database.

Results

We found that the expression level of

SUBMITTER: Cui X 

PROVIDER: S-EPMC10086116 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature